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Recreational Amenities and Features
Indulge in relaxation at the indoor pool or maintain your fitness routine in the on-site fitness center. Unwind by the cozy fireplace in the lobby or grab a snack from the convenient vending machine.
Complimentary Services and Offerings
Stay connected with free wireless internet access, enjoy a daily buffet breakfast, and make use of complimentary wired internet access. Benefit from amenities such as a business center, express check-in, and free self-parking.
Accommodations and Nearby Attractions
Retreat to one of the 92 guestrooms equipped with modern amenities. Explore nearby landmarks like Barnes Jewish South Campus and Suson Park, with various other attractions just a short drive away.
For a convenient and comfortable stay in St. Louis, book your stay at Hampton Inn & Suites St. Louis/South I-55 today!
Maximum number of pets per room 2
Only dogs and cats are allowed
Service animals are exempt from fees/restrictions
No rollaway/extra beds available
Contactless check-out is available
Maximum number of pets per room 2
Only dogs and cats are allowed
Service animals are exempt from fees/restrictions
No rollaway/extra beds available
Contactless check-out is available
Pets cannot be left unattended
Pets allowed
LGBTQ friendly
Professional property host/manager
Contactless check-in is available
Service animals are allowed
Very nice hotel with a very good breakfast. Room was very clean and the beds were very comfortable.
Lovely property, clean, well maintained. The breakfast lady Kathi is such a delight and love the breakfast scones. This hotel was located near our friends house....I would definitely recommend this hotel.
I liked everything about this Hampton Inn, from the staff, room, amenities, breakfast, cleanliness, location and parking are all superb.
Will definitely come back
Very clean, modern rooms with a welcoming staff.
Didn't use
Good
The staff was so helpful. We came for a funeral. Our room was not, ready, we needed to check in early. I was in consent contact with your staff about early check in, we needed to change clothes before going to the funeral. I was told they would do everything to accommodate us. The rooms were being cleaned when we arrived, but we would be late if we waited to change, so your staff allowed use to change in a vacant conference room, it was 5 of us. They check to see how long it would take us to get to the funeral. The staff was just so caring and sincere. We made it on time to share this difficult time with our family. Blessings to your staff. The Sanders family.
Really nice rooms and staff , good breakfast!
We stayed at the Hampton Inn, 4200 Midamerica Lane, I55 South, in St Louis, MO. on September 1, 2025. Honestly, we feel we had a strange encounter with the older lady checking us in at the front counter. First, the lady gave us a strange look as we walked in and her eyes kept looking at me and my lady friend who just happened to be white. I am African-American. Don’t know what that was all about, but she kept this serious look on her face and absolutely had no smiles for us. Hey, maybe she was having a bad day. But, after taking my credit card and checking my drivers license (extremely slow and closely), she then proceeded to asked me to write down the full description of the vehicle we arrived in. She specifically said, (as she look out the window at our car), give me a description of the car you came in outside. She requested the make, model, color of the car and any other description of the car. Honestly, this made me feel somewhat uncomfortable because this had never happened to me before at a Hilton property. And, I am a diamond's honors member. I’ve stayed at many Hampton Inn over the years. I would like to mention, there were no section on the check-in form that asked specifically for car descriptions and details so I had to write it in on the form. Does anyone know if this is a new policy or was this a racial discriminatory incident. Honestly , I just don’t know what happened.
Our room was cleaned by Tiff and it was in perfect condition. Pool area was clean as well as the lobby and dining area. You can tell the staff cares. Everyone was very hospitable at breakfast. I also love that you can tip the support staff through the qr code. Would highly reccomend
Jacqueline was amazing . We will be back to visit in the future
Nice place
A little confusing when asking for towels/ washcloths but seemed to work out on day 3!
Got in late and there was a “make-shift” pvc barrier with stop signs on it with a woman with a clipboard. We stopped and rolled down the window and SHE JUST WALKED RIGHT PAST US to the back of the truck. Got our tag then came up to the window and asked which hotel we’re staying. I said “Who are you!”? She got mad and said “I’m hotel SECURITY!” I replied “Ok, next time ID yourself for my safety and yours!”. As I drove off she said something with real attitude because of how she was shaking her head. Bad intro. But check in was awesome and room was great.
Everything was great! Clean, comfortable and breakfast was fantastic!
Great service. Hot coffee 24 hrs/day at the reception desk. Warm cookies every night at 8pm. Fitness center fully equipped. We stayed 3 nights and there's always a fear that if the hotel is bad, you're stuck for 3 days but this hotel is great. We enjoyed all 3 days. If we come back to St Louis we will definitely stay here.
I think breakfast could be better.
The best hotel staff I’ve ever encountered.
Went with family friends and we all stayed here and had a great experience.
The wallpaper in the bathroom was coming up in a few different places.
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