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Luxurious Accommodation
Experience the elegance and comfort of 21c Museum Hotel St Louis, offering 4-star rooms with modern amenities including air conditioning, flat-screen TVs, and plush bedding.
Art and Culture
Immerse yourself in art at our hotel, featuring a contemporary art museum within the premises, showcasing thought-provoking exhibitions and installations.
Relaxation and Dining
Unwind by taking a dip in the indoor pool or savor a delicious meal at the on-site restaurant. Enjoy a convenient stay with room service and a 24-hour front desk at your disposal.
Book your stay at 21c Museum Hotel St Louis for a perfect blend of luxury and artistry.
Guests are required to show a photo ID and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
When booking more than 7 rooms, different policies and additional supplements may apply.
Children of any age are allowed.
Children up to and including 17 years old stay for free when using an existing bed.
You haven't added any cots.
You haven't added any extra beds.
Public parking is possible at a location nearby (reservation is not needed) and charges may be applicable.
The friendly people and the artistic vibe as well as being able to get a craft cocktail with out leaving the hotel. The coffee shop was wonderful too! The valet/door lady Rose was a gem! Everyone was very nice and helpful!
It’s a little pricier than some of the other nice, boutique hotels.
My room was very clean 👌
Coffee
It’s in the center of the city, which was convenient because I was seeing a concert at Enterprise Center. So I could walk there and other places very easily. The art gallery was fantastic!!!!
The cleanliness was not up to par. I walked into the pool room / parlor and there were dust bunnies all over the floor like it hadn’t been swept or vacuumed in months. On the tables in the same room there were unknown fluids dried onto them. It’s obvious they hadn’t been wiped in goodness knows how long. Not impressive when I’m paying almost $200 a night. The bar is over priced. I don’t know if this happens all the time but I ran a tab with a debit card and ordered 2 drinks. One was $10 and the other was $8, tell me why my tab was $27 and some change??? There was no itemized statement on the receipt so I don’t know what the bartender rang in, I don’t know what I’m being taxed, or if there’s gratuity. I’ve never seen anything like that. Very strange indeed. My room was presentable but the toilet had not been cleaned properly, nor was there a trash can liner in the bathroom for garbage.
Amazing place and experience
My stay at **21c Museum Hotel St. Louis** was nothing short of an experience — not just a hotel stay, but a whole vibe. ✨
From the moment I walked in, I was surrounded by contemporary art that made the space feel curated, bold, and inspiring. It’s literally like sleeping inside a museum — but with luxury, comfort, and intention woven into every detail.
The rooms? Modern, sleek, and effortlessly stylish. The high ceilings, thoughtful design, and plush bedding made it hard to leave. Every corner felt Instagram-worthy without even trying.
The service was top-tier — warm, attentive, and genuinely welcoming. And let’s talk about the atmosphere: creative, elevated, and culturally rich. Whether you’re a business traveler, couple, or content creator looking for a stunning backdrop, this is the spot.
If you’re in St. Louis and want a stay that feels inspiring, artistic, and luxurious all at once, 21c is it. 10/10 — I’ll absolutely be back. 🖤
The room
Elevator wasn’t working
The hotel was beautiful! The best part was the museum! It was cozy.
Servers were exceptional
Selection for kids
Rooms are very nice
- until today they can not manage to give me an invoice of my stay: I asked at check out, I send mails and phoned: staff was not helpful at all (even to requests from booking.com customer service there are no reactions)
- breakfast: was one day quite chaotic with lack of food at 7:45 am. I had to leave without anything
The museum was beautiful.
The coffee shop is amazing 🤩
The rooms were nice and the bed was comfortable. Needs more room to walk n the bathroom needed some attention
Needs more room to walk n the bathroom needed some attention. Valet is too pricey
The Gallery and the customer service. The restaurant staff is amazing.
Food was great, ate at idol wolf resturant all 3 nights. Location was OK, but wished there had been more things we could have walked to (besides the City Museum).
See above re location - little you can do about that.
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